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Issue 10, 2011
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Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles

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Abstract

The palladium-catalyzed cyanation of Ar–X (X = I, Br, Cl, OTf, and H) allows for an efficient access towards benzonitriles. After its discovery in 1973 and following significant improvements in recent decades, this methodology has become nowadays the most popular for preparation of substituted aromatic nitriles. In this critical review, we summarize the important developments in this area from 2000 until 2010 (151 references).

Graphical abstract: Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles

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Publication details

The article was received on 07 Jan 2011 and first published on 28 Apr 2011


Article type: Critical Review
DOI: 10.1039/C1CS15004A
Chem. Soc. Rev., 2011,40, 5049-5067

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    Recent developments and perspectives in palladium-catalyzed cyanation of aryl halides: synthesis of benzonitriles

    P. Anbarasan, T. Schareina and M. Beller, Chem. Soc. Rev., 2011, 40, 5049
    DOI: 10.1039/C1CS15004A

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