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Issue 5, 2011
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Ball milling in organic synthesis: solutions and challenges

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During the last decade numerous protocols have been published using the method of ball milling for synthesis all over the field of organic chemistry. However, compared to other methods leaving their marks on the road to sustainable synthesis (e.g. microwave, ultrasound, ionic liquids) chemistry in ball mills is rather underrepresented in the knowledge of organic chemists. Especially, in the last three years the interest in this technique raised continuously, culminating in several high-quality synthetic procedures covering the whole range of organic synthesis. Thus, the present tutorial review will be focused on the highlights using this method of energy transfer and energy dissipation. The central aim is to motivate researchers to take notice of ball mills as chemical reactors, implementing this technique in everyday laboratory use and thus, pave the ground for future activities in this interdisciplinary field of research.

Graphical abstract: Ball milling in organic synthesis: solutions and challenges

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Article information

29 Nov 2010
10 Feb 2011
First published
08 Mar 2011

Chem. Soc. Rev., 2011,40, 2317-2329
Article type
Tutorial Review

Ball milling in organic synthesis: solutions and challenges

A. Stolle, T. Szuppa, S. E. S. Leonhardt and B. Ondruschka, Chem. Soc. Rev., 2011, 40, 2317
DOI: 10.1039/C0CS00195C

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