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Issue 39, 2011
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The effect of lipid oxidation on the water permeability of phospholipids bilayers

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Abstract

The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio.

Graphical abstract: The effect of lipid oxidation on the water permeability of phospholipids bilayers

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Publication details

The article was received on 01 Apr 2011, accepted on 15 Aug 2011 and first published on 06 Sep 2011


Article type: Paper
DOI: 10.1039/C1CP21009B
Phys. Chem. Chem. Phys., 2011,13, 17555-17563

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    The effect of lipid oxidation on the water permeability of phospholipids bilayers

    M. Lis, A. Wizert, M. Przybylo, M. Langner, J. Swiatek, P. Jungwirth and L. Cwiklik, Phys. Chem. Chem. Phys., 2011, 13, 17555
    DOI: 10.1039/C1CP21009B

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