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Issue 21, 2011
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Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy

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Abstract

Lipid domains in supported lipid layers serve as a popular model to gain insight into the processes associated with the compartmentalization of biological membranes into so-called lipid rafts. In this paper, we present reproducible tip-enhanced Raman spectra originating from a very small number of molecules in a lipid monolayer on a gold surface, probed by the apex of a nanometer-sized silver tip. For the first time, we show large (128 × 128 pixels), high-resolution (< 50 nm) tip-enhanced Raman images of binary lipid mixtures with full spectral information at each pixel.

Graphical abstract: Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy

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Article information


Submitted
09 Dec 2010
Accepted
09 Mar 2011
First published
23 Mar 2011

Phys. Chem. Chem. Phys., 2011,13, 9978-9981
Article type
Communication

Nanoscale chemical imaging of segregated lipid domains using tip-enhanced Raman spectroscopy

L. Opilik, T. Bauer, T. Schmid, J. Stadler and R. Zenobi, Phys. Chem. Chem. Phys., 2011, 13, 9978
DOI: 10.1039/C0CP02832K

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