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Issue 46, 2011
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Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

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Abstract

Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.

Graphical abstract: Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

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Publication details

The article was received on 08 Sep 2011, accepted on 13 Oct 2011 and first published on 31 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15557A
Chem. Commun., 2011,47, 12453-12455

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    Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

    O. Ohno, T. Chiba, S. Todoroki, H. Yoshimura, N. Maru, K. Maekawa, H. Imagawa, K. Yamada, A. Wakamiya, K. Suenaga and D. Uemura, Chem. Commun., 2011, 47, 12453
    DOI: 10.1039/C1CC15557A

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