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Issue 44, 2011
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Novel paramagnetic AT1 receptor antagonists

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Abstract

Novel paramagnetic selective angiotensin AT1 receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pKB estimates in the range 6.2–9.1. In addition, the sodium salt (11) of 4 (R = Bu) is able to protect against vascular injury in hypertensive rats as determined by its ability to attenuate the development of intimal thickening caused by balloon injury of the carotid artery.

Graphical abstract: Novel paramagnetic AT1 receptor antagonists

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Publication details

The article was received on 09 Aug 2011, accepted on 21 Sep 2011 and first published on 30 Sep 2011


Article type: Communication
DOI: 10.1039/C1CC14920B
Chem. Commun., 2011,47, 12083-12085

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    Novel paramagnetic AT1 receptor antagonists

    N. P. H. Tan, M. K. Taylor, S. E. Bottle, C. E. Wright, J. Ziogas, J. M. White, C. H. Schiesser and N. V. Jani, Chem. Commun., 2011, 47, 12083
    DOI: 10.1039/C1CC14920B

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