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Issue 39, 2011
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A general synthesis of dirhodium metallopeptides as MDM2 ligands

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Abstract

A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.

Graphical abstract: A general synthesis of dirhodium metallopeptides as MDM2 ligands

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Supplementary files

Article information


Submitted
29 May 2011
Accepted
23 Aug 2011
First published
12 Sep 2011

Chem. Commun., 2011,47, 10927-10929
Article type
Communication

A general synthesis of dirhodium metallopeptides as MDM2 ligands

A. N. Zaykov and Z. T. Ball, Chem. Commun., 2011, 47, 10927
DOI: 10.1039/C1CC13169A

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