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Issue 32, 2011
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An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification

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Abstract

A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme.

Graphical abstract: An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification

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Supplementary files

Article information


Submitted
28 May 2011
Accepted
27 Jun 2011
First published
13 Jul 2011

Chem. Commun., 2011,47, 9069-9071
Article type
Communication

An ultrasensitive colorimeter assay strategy for p53 mutation assisted by nicking endonuclease signal amplification

Z. Lin, W. Yang, G. Zhang, Q. Liu, B. Qiu, Z. Cai and G. Chen, Chem. Commun., 2011, 47, 9069
DOI: 10.1039/C1CC13146J

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