Zhenyu Lin, Weiqiang Yang, Guiyun Zhang, Qida Liu, Bin Qiu, Zongwei Cai and Guonan Chen
Chem. Commun., 2011,47, 9069-9071
DOI:
10.1039/C1CC13146J,
Communication
A novel catalytic colorimetric assay assisted by nicking endonuclease signal amplification (NESA) was developed. With the signal amplification, the detection limit of the p53 target gene can be as low as 1 pM, which is nearly 5 orders of magnitude lower than that of other previously reported colorimetric DNA detection strategies based on catalytic DNAzyme.
