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An octapeptide, GAGAGAGY, was obtained by a novel method, i.e. hydrolysing Bombyx mori silk fibroin. Afterward, a dodecanoic acid–peptide conjugation was synthesized. This amphiphile assembled into cylindrical nanofibers of planar β-sheets at pH 9 and twisted β-sheets at pH 4.

Graphical abstract: Self-assembly of a peptide amphiphile based on hydrolysed Bombyx mori silk fibroin

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