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Issue 26, 2011
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Flow-alignment of bicellar lipid mixtures: orientations of probe molecules and membrane-associated biomacromolecules in lipid membranes studied with polarized light

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Abstract

Bicelles are excellent membrane-mimicking hosts for a dynamic and structural study of solutes with NMR, but the magnetic fields required for their alignment are hard to apply to optical conditions. Here we demonstrate that bicellar mixtures can be aligned by shear forces in a Couette flow cell, to provide orientation of membrane-bound retinoic acid, pyrene and cytochrome c (cyt c) protein, conveniently studied with linear dichroism spectroscopy.

Graphical abstract: Flow-alignment of bicellar lipid mixtures: orientations of probe molecules and membrane-associated biomacromolecules in lipid membranes studied with polarized light

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Article information


Submitted
20 Apr 2011
Accepted
13 May 2011
First published
03 Jun 2011

Chem. Commun., 2011,47, 7356-7358
Article type
Communication

Flow-alignment of bicellar lipid mixtures: orientations of probe molecules and membrane-associated biomacromolecules in lipid membranes studied with polarized light

M. Kogan, T. Beke-Somfai and B. Nordén, Chem. Commun., 2011, 47, 7356
DOI: 10.1039/C1CC12313K

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