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Issue 21, 2011
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The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

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Abstract

Cisplatin, cis-[Pt(Cl2(NH3)2], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Graphical abstract: The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

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Publication details

The article was received on 21 Mar 2011, accepted on 07 Apr 2011 and first published on 28 Apr 2011


Article type: Communication
DOI: 10.1039/C1CC11627D
Chem. Commun., 2011,47, 6006-6008

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    The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

    W. Hu, Q. Luo, K. Wu, X. Li, F. Wang, Y. Chen, X. Ma, J. Wang, J. Liu, S. Xiong and P. J. Sadler, Chem. Commun., 2011, 47, 6006
    DOI: 10.1039/C1CC11627D

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