Issue 26, 2011
From the journal:

Chemical Communications

Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging†

Jae Hong Lee,‡a   Ju-Hoon So,‡ab   Jong Hyun Jeon,a   Eun Bok Choi,a   Yu-Ri Lee,b   Young-Tae Chang,c   Cheol-Hee Kim,*b   Myung Ae Bae*a  and  Jin Hee Ahn*a  

* Corresponding authors

a Bioorganic Division, Korea Research Institute of Chemical Technology, Daejeon, Korea
E-mail: jhahn@krict.re.kr, mbae@krict.re.kr
Fax: +82-42-860-7160
Tel: +82-42-860-7076

b Department of Biology and GRAST, Chungnam National University Daejeon, Korea
E-mail: zebrakim@cnu.ac.kr
Tel: +82-42-821-5494

c Department of Chemistry & Med Chem Program, National University of Singapore, and Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, A*STAR, Biopolis, Singapore

Abstract

A new small molecule probe for in vivolipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

Graphical abstract: Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

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Article information

DOI
https://doi.org/10.1039/C1CC11253H
Article type
Communication
Submitted
03 Mar 2011
Accepted
12 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 7500-7502

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Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

J. H. Lee, J. So, J. H. Jeon, E. B. Choi, Y. Lee, Y. Chang, C. Kim, M. A. Bae and J. H. Ahn, Chem. Commun., 2011, 47, 7500 DOI: 10.1039/C1CC11253H

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