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Issue 26, 2011
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Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

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Abstract

A new small molecule probe for in vivolipid imaging, LipidGreen (compound 5), was developed. LipidGreen stained lipid droplets in 3T3L1 cell lines and fat deposits in zebrafish without apparent toxicity up to 100 μM. The utility of LipidGreen as a drug screening platform for fat regulation was also demonstrated in live zebrafish.

Graphical abstract: Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

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Supplementary files

Article information


Submitted
03 Mar 2011
Accepted
12 Apr 2011
First published
09 May 2011

Chem. Commun., 2011,47, 7500-7502
Article type
Communication

Synthesis of a new fluorescent small molecule probe and its use for in vivolipid imaging

J. H. Lee, J. So, J. H. Jeon, E. B. Choi, Y. Lee, Y. Chang, C. Kim, M. A. Bae and J. H. Ahn, Chem. Commun., 2011, 47, 7500
DOI: 10.1039/C1CC11253H

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