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Issue 18, 2011
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First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

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Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

Graphical abstract: First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

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Article information


Submitted
10 Feb 2011
Accepted
15 Mar 2011
First published
31 Mar 2011

Chem. Commun., 2011,47, 5295-5297
Article type
Communication

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

G. Mercey, T. Verdelet, G. Saint-André, E. Gillon, A. Wagner, R. Baati, L. Jean, F. Nachon and P. Renard, Chem. Commun., 2011, 47, 5295
DOI: 10.1039/C1CC10787A

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