Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 26, 2011
Previous Article Next Article

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

Author affiliations

Abstract

Metabolic chiral inversion of 2-arylpropanoic acids (2-APAs; ‘profens’), such as ibuprofen, is important for pharmacological activity. Several 2-APA-CoA esters were good racemisation substrates for human AMACR 1A, suggesting a common chiral inversion pathway for all 2-APAs and an additional mechanism for their anti-cancer properties.

Graphical abstract: Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

Back to tab navigation

Supplementary files

Article information


Submitted
09 Feb 2011
Accepted
26 Apr 2011
First published
26 May 2011

Chem. Commun., 2011,47, 7332-7334
Article type
Communication

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—a potential mechanism for the anti-cancer effects of ibuprofen

T. J. Woodman, P. J. Wood, A. S. Thompson, T. J. Hutchings, G. R. Steel, P. Jiao, M. D. Threadgill and M. D. Lloyd, Chem. Commun., 2011, 47, 7332
DOI: 10.1039/C1CC10763A

Social activity

Search articles by author

Spotlight

Advertisements