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Issue 16, 2011
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Small-molecule fluorescent probes for specific RNA targets

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Abstract

A method was developed that uses small molecules as fluorescent probes to detect specific mRNAs. In this approach, the fluorescence of fluorophore–quencher conjugates is restored by the binding of an mRNA aptamer tag to the quencher segment of the molecules. The method allows real-time detection of mRNA transcripts in vitro.

Graphical abstract: Small-molecule fluorescent probes for specific RNA targets

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Publication details

The article was received on 20 Jan 2011, accepted on 25 Feb 2011 and first published on 17 Mar 2011


Article type: Communication
DOI: 10.1039/C1CC10393H
Chem. Commun., 2011,47, 4712-4714

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    Small-molecule fluorescent probes for specific RNA targets

    A. Murata, S. Sato, Y. Kawazoe and M. Uesugi, Chem. Commun., 2011, 47, 4712
    DOI: 10.1039/C1CC10393H

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