Issue 17, 2011
From the journal:

Chemical Communications

Real-time, in vivo monitoring and pharmacokinetics of valproic acidvia a novel biomarker in exhaled breath†

Gerardo Gamez,‡§a   Liang Zhu,§a   Andreas Disko,b   Huanwen Chen,c   Vladimir Azov,d   Konstantin Chingin,a   Günter Krämerb  and  Renato Zenobi*a  

* Corresponding authors

a Department of Chemistry and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland
E-mail: zenobi@org.chem.ethz.ch
Fax: +41 44 632 1292
Tel: +41 44 632 4376

b Schweizerisches Epilepsie-Zentrum, Bleulerstr. 60, CH-8008 Zürich, Switzerland

c Department of Applied Chemistry, East China Institute of Technology, Fuzhou 344000, China

d Department of Chemistry, University of Bremen, Loebener Str. NW 2C, D-28334 Bremen, Germany

Abstract

Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivodrug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy.

Graphical abstract: Real-time, in vivo monitoring and pharmacokinetics of valproic acidvia a novel biomarker in exhaled breath

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Article information

DOI
https://doi.org/10.1039/C1CC10343A
Article type
Communication
Submitted
18 Jan 2011
Accepted
10 Feb 2011
First published
04 Mar 2011

Chem. Commun., 2011,47, 4884-4886

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Real-time, in vivo monitoring and pharmacokinetics of valproic acidvia a novel biomarker in exhaled breath

G. Gamez, L. Zhu, A. Disko, H. Chen, V. Azov, K. Chingin, G. Krämer and R. Zenobi, Chem. Commun., 2011, 47, 4884 DOI: 10.1039/C1CC10343A

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