Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2011
Previous Article Next Article

A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F

Author affiliations

Abstract

The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling to achieve the first total synthesis of three members of the isodomoic acid family; the same alkyne can be envisaged as a precursor to several more of this class of amnesic shellfish toxins.

Graphical abstract: A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F

Back to tab navigation

Supplementary files

Article information


Submitted
04 Jan 2011
Accepted
31 Jan 2011
First published
24 Feb 2011

Chem. Commun., 2011,47, 3745-3747
Article type
Communication

A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F

G. Lemière, S. Sedehizadeh, J. Toueg, N. Fleary-Roberts and J. Clayden, Chem. Commun., 2011, 47, 3745
DOI: 10.1039/C1CC00048A

Social activity

Search articles by author

Spotlight

Advertisements