Issue 30, 2011
From the journal:

Chemical Communications

Detection of viral nucleoprotein binding to anti-influenza aptamersviaSERS†‡

Pierre Negri,a   Andreas Kage,b   Andreas Nitsche,c   Dieter Naumannc  and  Richard A. Dluhy*a  

* Corresponding authors

a Department of Chemistry, University of Georgia, Athens, USA
E-mail: pnegri@uga.edu, dluhy@uga.edu
Fax: +1 706 542 1950
Tel: +1 706 542 1950

b AptaRes AG, D-15749 Mittenwalde, Germany
E-mail: andreas.h.kage@tu-berlin.de
Fax: +49 (0) 33764 265498
Tel: +49 (0) 33764 265498

c Robert Koch Institut, Nordufer 20, D-13353 Berlin, Germany
E-mail: nitschea@rki.de, naumannd@rki.de
Fax: +49 (30) 45472606
Tel: +49 (30)45472259

Abstract

A highly sensitive surface-enhanced Raman (SERS)-based method for detection of influenza viral nucleoproteins is described. The intrinsic SERS spectrum of the aptamer–nucleoprotein complex provides direct evidence of binding between a polyvalent anti-influenza aptamer and the nucleoproteins of three influenza strains.

Graphical abstract: Detection of viral nucleoprotein binding to anti-influenza aptamersviaSERS

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Article information

DOI
https://doi.org/10.1039/C0CC05433J
Article type
Communication
Submitted
07 Dec 2010
Accepted
09 Jun 2011
First published
27 Jun 2011

Chem. Commun., 2011,47, 8635-8637

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Detection of viral nucleoprotein binding to anti-influenza aptamersviaSERS

P. Negri, A. Kage, A. Nitsche, D. Naumann and R. A. Dluhy, Chem. Commun., 2011, 47, 8635 DOI: 10.1039/C0CC05433J

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