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Issue 43, 2011
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A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups

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Abstract

A procedure for the radiosynthesis of aliphatic [18F]trifluoromethyl groups by reacting 1,1-difluorovinyl precursors with [18F]fluoride ions, resulting in the equivalent of direct nucleophilic addition of H[18F]F, has been developed. A variety of 18F-labelled model compounds were then obtained and two potential [18F]radiotracers were synthesised by a two step process starting from 1,1-difluorovin-2-yl 4-toluenesulfonate. The method is widely applicable for the synthesis of novel radiotracers in high radiochemical yields and good specific activity.

Graphical abstract: A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups

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Publication details

The article was received on 27 Aug 2011, accepted on 29 Sep 2011 and first published on 11 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15342K
Chem. Commun., 2011,47, 11873-11875

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    A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups

    P. J. Riss and F. I. Aigbirhio, Chem. Commun., 2011, 47, 11873
    DOI: 10.1039/C1CC15342K

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