Issue 37, 2011
From the journal:

Chemical Communications

Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform†

Jin Woo Bae,‡a   Ryan M. Pearson,‡a   Niladri Patra,b   Suhair Sunoqrot,a   Lela Vuković,b   Petr Král*b  and  Seungpyo Hong*a  

* Corresponding authors

a Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood St. Chicago, USA
E-mail: sphong@uic.edu
Fax: +1 312-996-0098
Tel: +1 312-413-8294

b Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St. Chicago, USA
E-mail: pkral@uic.edu
Fax: +1 312-996-0431
Tel: +1 312-996-6319

Abstract

PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1–2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

Graphical abstract: Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

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Article information

DOI
https://doi.org/10.1039/C1CC14331J
Article type
Communication
Submitted
18 Jul 2011
Accepted
05 Aug 2011
First published
22 Aug 2011

Chem. Commun., 2011,47, 10302-10304

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Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

J. W. Bae, R. M. Pearson, N. Patra, S. Sunoqrot, L. Vuković, P. Král and S. Hong, Chem. Commun., 2011, 47, 10302 DOI: 10.1039/C1CC14331J

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