Issue 37, 2011

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

Abstract

5,10,15,20-Tetrakis(N-(2-(1H-imidazol-4-yl)ethyl)benzamide)porphyrin produced twice as many singlet oxygen (1O2) molecules at pH 5.0 (quantum yield 0.53 ± 0.01) than at pH 7.4, whereas the 1O2 quenching rate was reduced by a factor of 2.5 for a pH change from 7.4 to 5.0.

Graphical abstract: Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
04 Jun 2011
Accepted
08 Aug 2011
First published
19 Aug 2011

Chem. Commun., 2011,47, 10311-10313

Imidazole-modified porphyrin as a pH-responsive sensitizer for cancer photodynamic therapy

X. Zhu, W. Lu, Y. Zhang, A. Reed, B. Newton, Z. Fan, H. Yu, P. C. Ray and R. Gao, Chem. Commun., 2011, 47, 10311 DOI: 10.1039/C1CC13328D

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