Issue 28, 2011
From the journal:

Chemical Communications

Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier†

Huihui Yan,b   Jiyao Wang,b   Peiwei Yi,c   Hao Lei,*c   Changyou Zhan,a   Cao Xie,a   Linglin Feng,d   Jun Qian,a   Jianhua Zhu,a   Weiyue Lua  and  Cong Li*a  

* Corresponding authors

a Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA,, School of Pharmacy, Fudan University, 826 Zhangheng Rd., Shanghai 201203, China
E-mail: congli@fudan.edu.cn
Fax: +86 21 5198 0100
Tel: +86 21 5198 0100

b Department of Gastroenterology, Zhongshan Hospital affiliated to Fudan University, 180 Fenglin Rd., Shanghai 200032, China

c State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics & Mathematics, The Chinese Academy of Sciences, 30# Xiaohongshan, Wuhan 430071, China
E-mail: leihao@wipm.ac.cn
Fax: +86 27 8719 9291
Tel: +8627 8719 9291

d National Population and Family Planning Key Laboratory of Contraceptives Drugs & Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Rd., Shanghai 200032, China

Abstract

A multimodal optical/paramagnetic nanoprobe, Den-Angio, was developed and demonstrated a capability to circumvent the blood brain barrier (BBB) and visualize brain tumors with high sensitivity in vivo. Den-Angio holds promise to pre-operatively localize brain tumors and make image-guided tumor resection possible during surgery.

Graphical abstract: Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier

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Article information

DOI
https://doi.org/10.1039/C1CC12007G
Article type
Communication
Submitted
08 Apr 2011
Accepted
27 Apr 2011
First published
31 May 2011

Chem. Commun., 2011,47, 8130-8132

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Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier

H. Yan, J. Wang, P. Yi, H. Lei, C. Zhan, C. Xie, L. Feng, J. Qian, J. Zhu, W. Lu and C. Li, Chem. Commun., 2011, 47, 8130 DOI: 10.1039/C1CC12007G

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