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Issue 26, 2011
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Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

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Abstract

Surface-Enhanced Raman Spectroscopy (SERS) was performed to detect label-free RNA. We defined conditions which make it possible to probe the four bases of RNA, in single strands of polyadenosine (pA), polyuridine (pU), polycytosine (pC) and polyguanosine (pG). We therefore present below a quantitative analysis of mixtures of non-hybridized single strands, based on the deconvolution of the SERS mixture spectrum into the relative contributions of the SERS spectra of each constituent.

Graphical abstract: Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

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Publication details

The article was received on 05 Apr 2011, accepted on 26 Apr 2011 and first published on 17 May 2011


Article type: Communication
DOI: 10.1039/C1CC11925G
Citation: Chem. Commun., 2011,47, 7425-7427
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    Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

    E. Prado, N. Daugey, S. Plumet, L. Servant and S. Lecomte, Chem. Commun., 2011, 47, 7425
    DOI: 10.1039/C1CC11925G

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