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Issue 26, 2011
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Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

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Abstract

Surface-Enhanced Raman Spectroscopy (SERS) was performed to detect label-free RNA. We defined conditions which make it possible to probe the four bases of RNA, in single strands of polyadenosine (pA), polyuridine (pU), polycytosine (pC) and polyguanosine (pG). We therefore present below a quantitative analysis of mixtures of non-hybridized single strands, based on the deconvolution of the SERS mixture spectrum into the relative contributions of the SERS spectra of each constituent.

Graphical abstract: Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

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Supplementary files

Article information


Submitted
05 Apr 2011
Accepted
26 Apr 2011
First published
17 May 2011

Chem. Commun., 2011,47, 7425-7427
Article type
Communication

Quantitative label-free RNA detection using surface-enhanced Raman spectroscopy

E. Prado, N. Daugey, S. Plumet, L. Servant and S. Lecomte, Chem. Commun., 2011, 47, 7425
DOI: 10.1039/C1CC11925G

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