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Issue 23, 2011
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The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

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Abstract

A palladium-catalyzed cyanation of the 3-position of indole sp2 C–H bonds by the combination of NH4HCO3 and DMSO as the “CN” source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.

Graphical abstract: The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

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Publication details

The article was received on 20 Mar 2011, accepted on 19 Apr 2011 and first published on 10 May 2011


Article type: Communication
DOI: 10.1039/C1CC11603G
Chem. Commun., 2011,47, 6725-6727

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    The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

    X. Ren, J. Chen, F. Chen and J. Cheng, Chem. Commun., 2011, 47, 6725
    DOI: 10.1039/C1CC11603G

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