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Issue 23, 2011
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The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

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Abstract

A palladium-catalyzed cyanation of the 3-position of indole sp2 C–H bonds by the combination of NH4HCO3 and DMSO as the “CN” source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.

Graphical abstract: The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

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Supplementary files

Article information


Submitted
20 Mar 2011
Accepted
19 Apr 2011
First published
10 May 2011

Chem. Commun., 2011,47, 6725-6727
Article type
Communication

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

X. Ren, J. Chen, F. Chen and J. Cheng, Chem. Commun., 2011, 47, 6725 DOI: 10.1039/C1CC11603G

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