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Issue 35, 2011
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A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

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Abstract

Many Ru and Os systems display photoactive 3MLCT states. Systems activated by therapeutic window light in the absence of O2 remain elusive. [(bpy)2Os(dpp)RhCl2(phen)]3+ photobinds and photocleaves DNA under red light in an oxygen independent manner, due to molecular design involving one Os chromophore coupled to a photoactive cis-RhIIICl2 moiety.

Graphical abstract: A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

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Publication details

The article was received on 17 Mar 2011, accepted on 19 Apr 2011 and first published on 13 Jun 2011


Article type: Communication
DOI: 10.1039/C1CC11562F
Chem. Commun., 2011,47, 9786-9788

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    A new Os,Rh bimetallic with O2 independent DNA cleavage and DNA photobinding with red therapeutic light excitation

    J. Wang, S. L. H. Higgins, B. S. J. Winkel and K. J. Brewer, Chem. Commun., 2011, 47, 9786
    DOI: 10.1039/C1CC11562F

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