Issue 17, 2011
From the journal:

Chemical Communications

Positional photocleavage control of DNA-based nanoswitches†

Allen K. Mok,a   Nancy A. Kedzierski,a   Paul N. Chunga  and  Philip S. Lukeman*a  

* Corresponding authors

a California State Polytechnic University Pomona, Department of Chemistry, 3801 W Temple Avenue, Pomona, USA
E-mail: psl@csupomona.edu
Web: http://www.csupomona.edu/%E2%88%BCpsl
Fax: +1 909 869 4344
Tel: +1 909 869 3657

Abstract

DNA-based switches are currently operated by manual solution-phase addition of ‘set-strands’. We demonstrate another operation method—sterically inaccessible ‘set-strands’, released from a surface into solution by spatially controlled photocleavage. This technique will enable microarrays of set-strands to operate many DNA-based switches in self-contained computational and diagnostic devices.

Graphical abstract: Positional photocleavage control of DNA-based nanoswitches

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Article information

DOI
https://doi.org/10.1039/C1CC10292C
Article type
Communication
Submitted
16 Jan 2011
Accepted
07 Feb 2011
First published
21 Feb 2011

Chem. Commun., 2011,47, 4905-4907

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Positional photocleavage control of DNA-based nanoswitches

A. K. Mok, N. A. Kedzierski, P. N. Chung and P. S. Lukeman, Chem. Commun., 2011, 47, 4905 DOI: 10.1039/C1CC10292C

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