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Issue 23, 2011
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Acid controlled diastereoselectivity in asymmetric aldol reaction of cycloketones with aldehydes using enamine-based organocatalysts

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Abstract

The example of syn-aldol reaction of cyclohexanone to aldehyde was demonstrated based on chiral diamine organocatalysts and it was realized either by increasing the molecular size of acid additives or by introducing a hydrogen-bond donor into acid additives.

Graphical abstract: Acid controlled diastereoselectivity in asymmetric aldol reaction of cycloketones with aldehydes using enamine-based organocatalysts

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Article information


Submitted
27 Nov 2010
Accepted
20 Apr 2011
First published
10 May 2011

Chem. Commun., 2011,47, 6716-6718
Article type
Communication

Acid controlled diastereoselectivity in asymmetric aldol reaction of cycloketones with aldehydes using enamine-based organocatalysts

J. Gao, S. Bai, Q. Gao, Y. Liu and Q. Yang, Chem. Commun., 2011, 47, 6716
DOI: 10.1039/C0CC05224H

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