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Issue 12, 2011
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Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

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Abstract

The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-L-lysine) core with a redox-sensitive disulfide linkage.

Graphical abstract: Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

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Publication details

The article was received on 16 Nov 2010, accepted on 27 Jan 2011 and first published on 16 Feb 2011


Article type: Communication
DOI: 10.1039/C0CC04983B
Chem. Commun., 2011,47, 3550-3552

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    Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

    H. Wen, H. Dong, W. Xie, Y. Li, K. Wang, G. M. Pauletti and D. Shi, Chem. Commun., 2011, 47, 3550
    DOI: 10.1039/C0CC04983B

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