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Issue 9, 2011
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Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

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Abstract

An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.

Graphical abstract: Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

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Publication details

The article was received on 18 Oct 2010, accepted on 01 Dec 2010 and first published on 20 Dec 2010


Article type: Communication
DOI: 10.1039/C0CC04481D
Chem. Commun., 2011,47, 2688-2690

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    Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates

    A. G. O'Brien, F. Lévesque and P. H. Seeberger, Chem. Commun., 2011, 47, 2688
    DOI: 10.1039/C0CC04481D

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