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Issue 3, 2011
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Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

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Abstract

In this communication, we demonstrate for the first time the proof of concept that carbon nanoparticles (CNPs) can be used as an effective fluorescent sensing platform for nucleic acid detection with selectivity down to single-base mismatch. The dye-labeled single-stranded DNA (ssDNA) probe is adsorbed onto the surface of the CNPvia π–π interaction, quenching the dye. In the target assay, a double-stranded DNA (dsDNA) hybrid forms, recovering dye fluorescence.

Graphical abstract: Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

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Article information


Submitted
10 Oct 2010
Accepted
29 Oct 2010
First published
15 Nov 2010

Chem. Commun., 2011,47, 961-963
Article type
Communication

Nucleic acid detection using carbon nanoparticles as a fluorescent sensing platform

H. Li, Y. Zhang, L. Wang, J. Tian and X. Sun, Chem. Commun., 2011, 47, 961
DOI: 10.1039/C0CC04326E

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