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Issue 3, 2011
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Ribonuclease S redux

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Abstract

The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemistry, intrinsic limitations compromise its utility. Modern methods are shown to overcome those limitations and enable new applications.

Graphical abstract: Ribonuclease S redux

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Article information


Submitted
14 Sep 2010
Accepted
05 Oct 2010
First published
16 Nov 2010

Chem. Commun., 2011,47, 973-975
Article type
Communication

Ribonuclease S redux

R. W. Watkins, U. Arnold and R. T. Raines, Chem. Commun., 2011, 47, 973
DOI: 10.1039/C0CC03864D

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