Probing the stereoselectivity of P-glycoprotein—synthesis, biological activity and
ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines
A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of diastereoisomers. Docking studies into a homology model of human P-gp provide first insights into potential binding areas for these compounds.
- This article is part of the themed collection: Enzymes and Proteins