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Issue 4, 2011
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Determination of strychnine in strychnos nux-vomica crude and detoxified seeds by voltammetric method using a carbon paste electrode incorporated with gold nanoparticles

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Abstract

A new method using a carbon paste electrode modified with gold nanoparticles (GNPs/CPE) was developed and validated for determination of strychnine (ST) in Strychnos nux-vomica seeds. The modified carbon paste electrode consists of 24 nm-diameter colloidal gold nanoparticles resulting in an electrode that exhibits a significant catalytic effect toward the electrochemical oxidation of ST in a 0.2 M Britton-Robinson buffer solution (pH 7.0). The peak current increases linearly with the ST concentration within the molar concentration ranges of 8.00 × 10−6 to 3.50 × 10−5 M and 3.50 × 10−5 to 1.15 × 10−3 M. The detection limit (signal to noise > 3) for ST was found to be 4.6 × 10−7 M, respectively. In this work, voltammetric methods such as cyclic voltammetry, chronocoulometry and differential pulse voltammetry were used. The method was then successfully applied to the determination of ST in Strychnos nux-vomica crude and detoxified seeds

Graphical abstract: Determination of strychnine in strychnos nux-vomica crude and detoxified seeds by voltammetric method using a carbon paste electrode incorporated with gold nanoparticles

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Publication details

The article was received on 01 Nov 2010, accepted on 22 Feb 2011 and first published on 08 Mar 2011


Article type: Paper
DOI: 10.1039/C0AY00658K
Anal. Methods, 2011,3, 872-876

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    Determination of strychnine in strychnos nux-vomica crude and detoxified seeds by voltammetric method using a carbon paste electrode incorporated with gold nanoparticles

    M. Behpour, S. M. Ghoreishi, M. Khayatkashani and M. Motaghedifar, Anal. Methods, 2011, 3, 872
    DOI: 10.1039/C0AY00658K

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