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Issue 2, 2011
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Transient isotachophoresis with field-amplified sample injection for on-line preconcentration and enantioseparation of some β-agonists

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Abstract

Transient isotachophoresis with field-amplified sample injection (FASI), using β-CD as the chiral selector and tetrabutylammonium hydroxide (TBAOH) as the additive, was applied for on-line preconcentration and enantioseparation of three β-agonists, namely, cimaterol, clenbuterol and terbutaline. The experimental conditions for both simultaneous enantioseparation and on-line preconcentration methods have been investigated in detail. Under the optimum conditions, the detection limits (defined as S/N = 3) of this method were found to be 1 ng mL−1 for all three pairs of β-agonists enantiomers. Compared with conventional electrokinetic injection, the enhancement factors were greatly improved to be 250-fold. Finally, the proposed method has been applied for the analysis of human urine samples.

Graphical abstract: Transient isotachophoresis with field-amplified sample injection for on-line preconcentration and enantioseparation of some β-agonists

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Article information


Submitted
14 Sep 2010
Accepted
12 Oct 2010
First published
08 Dec 2010

Anal. Methods, 2011,3, 294-298
Article type
Paper

Transient isotachophoresis with field-amplified sample injection for on-line preconcentration and enantioseparation of some β-agonists

L. Huang, Q. Lin, Y. Chen and G. Chen, Anal. Methods, 2011, 3, 294
DOI: 10.1039/C0AY00556H

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