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Issue 1, 2011
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Rapid prototyping of polymeric electrophoresis microchips with integrated copper electrodes for contactless conductivity detection

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Abstract

A simple and easy approach to produce polymeric microchips with integrated copper electrodes for capacitively coupled contactless conductivity detection (C4D) is described. Copper electrodes were fabricated using a printed circuit board (PCB) as an inexpensive thin-layer of metal. The electrode layout was first drawn and laser printed on a wax paper sheet. The toner layer deposited on the paper sheet was thermally transferred to the PCB surface working as a mask for wet chemical etching of the copper layer. After the etching step, the toner was removed with an acetonitrile-dampened cotton. A poly(ethylene terephthalate) (PET) film coated with a thin thermo-sensitive adhesive layer was used to laminate the PCB plate providing an insulator layer of the electrodes to perform C4D measurements. Electrophoresis microchannels were fabricated in poly(dimethylsiloxane) (PDMS) by soft lithography and reversibly sealed against the PET film. These hybrid PDMS/PET chips exhibited a stable electroosmotic mobility of 4.25 ± 0.04 × 10−4 V cm−2 s−1, at pH 6.1, over fifty runs. Efficiencies ranging from 1127 to 1690 theoretical plates were obtained for inorganic cations.

Graphical abstract: Rapid prototyping of polymeric electrophoresis microchips with integrated copper electrodes for contactless conductivity detection

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Publication details

The article was received on 06 Aug 2010, accepted on 19 Oct 2010 and first published on 04 Nov 2010


Article type: Paper
DOI: 10.1039/C0AY00486C
Anal. Methods, 2011,3, 168-172

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    Rapid prototyping of polymeric electrophoresis microchips with integrated copper electrodes for contactless conductivity detection

    W. K. Tomazelli Coltro, J. A. Fracassi da Silva and E. Carrilho, Anal. Methods, 2011, 3, 168
    DOI: 10.1039/C0AY00486C

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