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Issue 5, 2011
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Dendrimer modified graphite sensors for detection of anticancer drugDaunorubicin by voltammetry and electrochemical impedance spectroscopy

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Abstract

The development of amino-terminated G4 PAMAM dendrimer (PDR) modified disposable electrodes were developed as the first time in our study by using the dendrimer modified disposable graphite (PDR-PGE) and multiwalled carbon nanotube based screen-printed graphite (PDR-MWCNT-SPE) electrodes. Firstly, the microscopic characterization of bare PGEs and PDR modified PGEs was performed. These sensors were then applied for electrochemical monitoring of an anticancer drug, Daunorubicin (DNR). The enhanced oxidation signal of DNR was measured at +0.50 V by using differential pulse voltammetry (DPV) in combination with the PDR-PGEs. The detection limit, estimated from S/N = 3, corresponds accordingly to 317 nM and 128 nM for DNR respectively at the PGE and PDR-PGE. The voltammetric results were consistent with electrochemical impedance spectroscopy (EIS) that was used to characterize the successful modification of PDR onto the surface of PGE and MWCNT-SPE.

Graphical abstract: Dendrimer modified graphite sensors for detection of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy

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Article information


Submitted
27 May 2010
Accepted
10 Dec 2010
First published
04 Jan 2011

Analyst, 2011,136, 1041-1045
Article type
Paper

Dendrimer modified graphite sensors for detection of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy

A. Erdem, H. Karadeniz and A. Caliskan, Analyst, 2011, 136, 1041
DOI: 10.1039/C0AN00357C

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