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Issue 6, 2011
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Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN

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Abstract

Controlled H-aggregation of single Pc-labeled oligonucleotides is utilized as a fluorescence quenching system to discern changes in enzyme activity for the discovery of inhibitors for Long Interspersed Element 1 endonuclease (L1-EN), which is involved in genome instability and implicated in many different diseases.

Graphical abstract: Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN

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Publication details

The article was received on 08 Oct 2010, accepted on 16 Dec 2010 and first published on 11 Jan 2011


Article type: Communication
DOI: 10.1039/C0AN00782J
Analyst, 2011,136, 1103-1105

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    Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN

    I. V. Nesterova, C. A. Bennett, S. S. Erdem, R. P. Hammer, P. L. Deininger and S. A. Soper, Analyst, 2011, 136, 1103
    DOI: 10.1039/C0AN00782J

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