Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 6, 2011
Previous Article Next Article

Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

Author affiliations

Abstract

The continuous surveillance of glucose concentration reduces short-term risks and long-term complications for people with diabetes mellitus, a disorder of glucose metabolism. As a first step towards the continuous monitoring of glucose, reagent-free transmission spectroscopy in the mid-infrared region has been carried out in vitro using a quantum cascade laser and an optical silver halide fiber. A 30 μm gap in the fiber allowed for transmission spectroscopy of aqueous glucose solutions at a wavelength of 9.69 μm, which is specific to a molecular vibration of glucose. A noise-equivalent concentration as low as 4 mg/dL was achieved at an average power of 1.8 mW and an integration time of 50 s. This is among the most precise of glucose measurements using mid-infrared spectroscopy. Even with the very low average laser power of 0.07 mW the sensitivity of previous results (using a fiber optical evanescent field analysis) has been improved upon by almost one order of magnitude. Finally, the impact of potentially interfering substances such as other carbohydrates was analyzed.

Graphical abstract: Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

Back to tab navigation

Article information


Submitted
17 Jul 2010
Accepted
21 Dec 2010
First published
27 Jan 2011

Analyst, 2011,136, 1192-1198
Article type
Paper

Continuous glucose monitoring by means of mid-infrared transmission laser spectroscopyin vitro

C. Vrančić, A. Fomichova, N. Gretz, C. Herrmann, S. Neudecker, A. Pucci and W. Petrich, Analyst, 2011, 136, 1192
DOI: 10.1039/C0AN00537A

Social activity

Search articles by author

Spotlight

Advertisements