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Issue 6, 2011
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Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains

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Abstract

Tip-enhanced Raman spectroscopy (TERS) is a highly sensitive spectroscopic technique which combines the advantages of optical spectroscopy with the requirements needed for the characterization of biological nano-structures. In this study, TERS was used to investigate the applicability of this spectroscopic technique for the detection of different virus strains like avipoxvirus and adeno-associated virus. TERS spectra obtained from different particles of the same virus strain show variations in relative peak intensities and positions of most spectral features observed. These spectral variations were higher for the larger avipoxvirus particles (∅ ≈ 350 nm) than for the smaller adeno-associated virus particles (∅ ≈ 26 nm).

Graphical abstract: Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains

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Article information


Submitted
16 Jul 2010
Accepted
23 Dec 2010
First published
26 Jan 2011

Analyst, 2011,136, 1148-1152
Article type
Paper

Evaluation of tip-enhanced Raman spectroscopy for characterizing different virus strains

P. Hermann, A. Hermelink, V. Lausch, G. Holland, L. Möller, N. Bannert and D. Naumann, Analyst, 2011, 136, 1148
DOI: 10.1039/C0AN00531B

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