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Issue 1, 2011
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Anti-aggregation of gold nanoparticle-based colorimetric sensor for glutathione with excellent selectivity and sensitivity

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Abstract

For the widely used Au nanoparticles (AuNPs)-based colorimetric probe, AuNPs generally change from the dispersion to the aggregation state and corresponding colors turn from red to blue concomitantly. In previous studies, there are few probes based on the anti-aggregation of AuNPs though anti-aggregation of AuNPs is preferable to aggregation to achieve higher selectivity. In this manuscript, a fast and simple but sensitive and selective sensor suitable for on-site and real-time detection of glutathione (GSH) has been developed based on the anti-aggregation of AuNPs. The sensor has a LOD of 8 nM and excellent selectivity toward GSH by a factor of 200-fold or more relative to natural amino acids as well as homocysteine (Hcys) and glutathione disulfide (GSSG). The dynamic range of the sensor can be tuned simply by adjusting the amount of aggregation agent used.

Graphical abstract: Anti-aggregation of gold nanoparticle-based colorimetric sensor for glutathione with excellent selectivity and sensitivity

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Publication details

The article was received on 29 Jun 2010, accepted on 07 Sep 2010 and first published on 07 Oct 2010


Article type: Paper
DOI: 10.1039/C0AN00452A
Analyst, 2011,136, 196-200

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    Anti-aggregation of gold nanoparticle-based colorimetric sensor for glutathione with excellent selectivity and sensitivity

    Y. Li, P. Wu, H. Xu, H. Zhang and X. Zhong, Analyst, 2011, 136, 196
    DOI: 10.1039/C0AN00452A

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