Issue 17, 2010
From the journal:

Soft Matter

Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimine

Ladan Parhamifar,a   Anna K. Larsen,a   A. Christy Hunter,b   Thomas L. Andresenc  and  S. Moein Moghimi*a  

* Corresponding authors

a Centre for Pharmaceutical Nanotechnology and Nanotoxicology, Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Universitetsparken 2, Copenhagen Ø, Denmark
E-mail: momo@farma.ku.dk

b Molecular Targeting and Polymer Toxicology Group, School of Pharmacy, University of Brighton, Brighton, UK

c Department of Micro- and Nanotechnology, DTU Nanotech, Technical University of Denmark, Frederiksborgvej 399, Roskilde, Denmark

Abstract

This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.

Graphical abstract: Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimine

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Article information

DOI
https://doi.org/10.1039/C000190B
Article type
Highlight
Submitted
07 Jan 2010
Accepted
08 Mar 2010
First published
21 Apr 2010

Soft Matter, 2010,6, 4001-4009

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Polycation cytotoxicity: a delicate matter for nucleic acid therapy—focus on polyethylenimine

L. Parhamifar, A. K. Larsen, A. C. Hunter, T. L. Andresen and S. M. Moghimi, Soft Matter, 2010, 6, 4001 DOI: 10.1039/C000190B

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