Jump to main content
Jump to site search

Issue 11, 2010
Previous Article Next Article

Tunable hydrogel morphology viaself-assembly of amphiphilic pentablock copolypeptides

Author affiliations

Abstract

Hydrogels assembled from symmetric amphiphilic pentablock copolypeptides were investigated using rheology and cryogenic transmission electron microscopy (cryoTEM). Due to the presence of two α-helical hydrophobic segments per chain, the pentablocks have the potential for organized intrachain folding, akin to natural proteins, in addition to intermolecular assembly. We found that variation of the central hydrophilic segment lengths in the copolymers enabled precise tuning of assembly morphology and hydrogel properties. CryoTEM characterization revealed that the hydrogels are nanoporous networks composed of branched and entangled tape-like fibrils, where average fibril length varied with the length of hydrophilic spacer between the hydrophobic domains. The pentablock architecture in these copolymers thus allowed additional control over self-assembled morphology and substantial enhancement of hydrogel properties.

Graphical abstract: Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides

Back to tab navigation

Supplementary files

Article information


Submitted
23 Dec 2009
Accepted
07 Apr 2010
First published
30 Apr 2010

Soft Matter, 2010,6, 2546-2551
Article type
Paper

Tunable hydrogel morphology via self-assembly of amphiphilic pentablock copolypeptides

Z. Li and T. J. Deming, Soft Matter, 2010, 6, 2546 DOI: 10.1039/B927137F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements