Dendronized cavitands: A step towards a synthetic viral capsid?

Abstract

Dendronized cavitands represent unique macromolecular hosts for encapsulation of biologically relevant guests. They combine the highly specific guest binding exhibited by deep-cavity cavitands, with the modular yet monodisperse macromolecular structure provided by dendrimers. Because these structures retain the ability to assemble into dimeric capsules, they resemble a simplified synthetic analog of viral capsids, displaying a modular, functionalizable outer coating while providing a protective cavity for a range of small-molecule payloads. This article highlights their preparation, their characterization, and their unique potential for probing in vivo drug delivery.