Jump to main content
Jump to site search

Issue 2, 2010
Previous Article Next Article

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Author affiliations

Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Graphical abstract: Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Back to tab navigation

Supplementary files

Article information


Submitted
25 Jan 2010
Accepted
12 Feb 2010
First published
25 May 2010

Chem. Sci., 2010,1, 206-209
Article type
Edge Article

Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

D. Morisaki, H. Kim, H. Inoue, H. Terauchi, S. Kuge, A. Naganuma, Y. Wataya, H. Tokuyama, M. Ihara and K. Takasu, Chem. Sci., 2010, 1, 206
DOI: 10.1039/C0SC00125B

Social activity

Search articles by author

Spotlight

Advertisements