Issue 20, 2010
From the journal:

Organic & Biomolecular Chemistry

A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles†

Chhanda Mukhopadhyay,*a   Pradip Kumar Tapaswia  and  Ray J. Butcherb  

* Corresponding authors

a Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata-700009, India
E-mail: cmukhop@yahoo.co.in
Tel: +91-33-23371104

b Department of Chemistry, Howard University, Washington DC, USA

Abstract

An efficient and highly versatile method for the synthesis of diverse regiospecific 1-arylbenzotriazoles being important medicinal scaffolds, by the copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes of 2-haloaryldiazonium salts in PEG-water has been developed. A very simple reaction protocol, large number of substrate affordability and excellent yields are the main features of this methodology.

Graphical abstract: A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

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Article information

DOI
https://doi.org/10.1039/C0OB00177E
Article type
Paper
Submitted
27 May 2010
Accepted
14 Jul 2010
First published
31 Aug 2010

Org. Biomol. Chem., 2010,8, 4720-4729

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A ligand-free copper (1) catalysed intramolecular N-arylation of diazoaminobenzenes in PEG-water: an expeditious protocol towards regiospecific 1-aryl benzotriazoles

C. Mukhopadhyay, P. K. Tapaswi and R. J. Butcher, Org. Biomol. Chem., 2010, 8, 4720 DOI: 10.1039/C0OB00177E

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