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Issue 13, 2010
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Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins

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Abstract

Quinidine was found to catalyze the Michael addition of unprotected 3-substituted oxindoles to nitroolefins in excellent yield and moderate to good diastereoselectivity. Bifunctional quinidine derived thiourea catalyst 10 could catalyze this reaction to afford the major diastereomer in up to 85% ee.

Graphical abstract: Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins

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The article was received on 09 Mar 2010, accepted on 04 May 2010 and first published on 17 May 2010


Article type: Communication
DOI: 10.1039/C004037A
Org. Biomol. Chem., 2010,8, 2912-2914

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    Organocatalytic Michael addition of unprotected 3-substituted oxindoles to nitroolefins

    M. Ding, F. Zhou, Z. Qian and J. Zhou, Org. Biomol. Chem., 2010, 8, 2912
    DOI: 10.1039/C004037A

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