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Issue 10, 2010
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Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment

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Abstract

Dermacoccus abyssi sp. nov., strains MT1.1 and MT1.2 are actinomycetes isolated from Mariana Trench sediment at a depth of 10 898 m. Fermentation using ISP2 and 410 media, respectively, lead to production of seven new oxidized and reduced phenazine-type pigments, dermacozines A–G (1–7), together with the known phenazine-1-carboxylic acid (8) and phenazine-1,6-dicarboxylic acid (9). Extensive use was made of 1D and 2D-NMR data, and high resolution MS to determine the structures of the compounds. To confirm the structure of the most complex pentacyclic analogue (5) we made use of electronic structure calculations to compare experimental and theoretical UV-Vis spectra, which confirmed a novel structural class of phenazine derivatives, the dermacozines. The absolute stereochemistry of dermacozine D (4) was determined as S by a combination of CD spectroscopy and electronic structure calculations. Dermacozines F (6) and G (7) exhibited moderate cytotoxic activity against leukaemia cell line K562 with IC50 values of 9 and 7 μM, respectively, while the highest radical scavenger activity was observed for dermacozine C (3) with an IC50 value of 8.4 μM.

Graphical abstract: Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment

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Supplementary files

Article information


Submitted
21 Jan 2010
Accepted
22 Feb 2010
First published
18 Mar 2010

Org. Biomol. Chem., 2010,8, 2352-2362
Article type
Paper

Dermacozines, a new phenazine family from deep-sea dermacocci isolated from a Mariana Trench sediment

W. M. Abdel-Mageed, B. F. Milne, M. Wagner, M. Schumacher, P. Sandor, W. Pathom-aree, M. Goodfellow, A. T. Bull, K. Horikoshi, R. Ebel, M. Diederich, H. Fiedler and M. Jaspars, Org. Biomol. Chem., 2010, 8, 2352
DOI: 10.1039/C001445A

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