Issue 7, 2010

Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of α-galactosidase§

Abstract

A new and short synthesis of hitherto unreported stereo analogue of amino-modified five-membered iminocyclitols from readily available tri-O-benzyl-D-glucal is described. Significantly, glycosidase inhibition studies of alkylamino substituted iminocyclitols display a high degree of selectivity towards α-galactosidase.

Graphical abstract: Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of α-galactosidase

Supplementary files

Article information

Article type
Communication
Submitted
11 Dec 2009
Accepted
02 Feb 2010
First published
15 Feb 2010

Org. Biomol. Chem., 2010,8, 1527-1530

Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of α-galactosidase

M. Ganesan, R. V. Madhukarrao and N. G. Ramesh, Org. Biomol. Chem., 2010, 8, 1527 DOI: 10.1039/B926123K

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