Issue 2, 2010
From the journal:

Organic & Biomolecular Chemistry

Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions†

Dhevalapally B. Ramachary,*a   Rumpa Mondala  and  Chintalapudi Venkaiaha  

* Corresponding authors

a School of Chemistry, University of Hyderabad, Hyderabad-500 046, India
E-mail: ramsc@uohyd.ernet.in
Fax: +91-40-23012460

Abstract

An efficient amino acid-/self-/base-/ruthenium-/thermal-catalyzed two-step process for the synthesis of functionalized drug-like carbocycles was achieved through combinations of cascade TCRA/C-allylation/enyne-RCM/Diels–Alder reactions as key steps starting from simple acyclic substrates. In this communication, we report the two-step synthesis of drug-like carbocycles through a combination of organocatalysis with ruthenium-catalysis.

Graphical abstract: Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

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Article information

DOI
https://doi.org/10.1039/B920152A
Article type
Communication
Submitted
28 Sep 2009
Accepted
19 Oct 2009
First published
28 Oct 2009

Org. Biomol. Chem., 2010,8, 321-325

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Rapid two-step synthesis of drug-like polycyclic substances by sequential multi-catalysis cascade reactions

D. B. Ramachary, R. Mondal and C. Venkaiah, Org. Biomol. Chem., 2010, 8, 321 DOI: 10.1039/B920152A

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