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Issue 4, 2010
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Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

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Abstract

Fluorescent cross-linked nanoparticles with variable fluorophore loading amounts, locations, and particle sizes were synthesized from sequential one-pot functionalization/cross-linking of block copolymer micelles with amine-terminated dye and cross-linker molecules, via reductive amination and amidation. The fluorescence quantum yield and brightness of these nanoparticles were evaluated by steady-state and dynamic fluorescence methods. The results demonstrate that the quantum yield and brightness of the fluorescent nanoparticles correlated directly with the number of dyes/nanoparticle and the nanoparticle size. A strategy to increase the fluorescence brightness of nanoparticles with fluorescein and near-infrared dyes is proposed.

Graphical abstract: Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

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Supplementary files

Article information


Submitted
13 Oct 2009
Accepted
08 Dec 2009
First published
08 Feb 2010

Nanoscale, 2010,2, 548-558
Article type
Paper

Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

G. Sun, M. Y. Berezin, J. Fan, H. Lee, J. Ma, K. Zhang, K. L. Wooley and S. Achilefu, Nanoscale, 2010, 2, 548
DOI: 10.1039/B9NR00304E

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