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Issue 4, 2010
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Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

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Abstract

Fluorescent cross-linked nanoparticles with variable fluorophore loading amounts, locations, and particle sizes were synthesized from sequential one-pot functionalization/cross-linking of block copolymer micelles with amine-terminated dye and cross-linker molecules, via reductive amination and amidation. The fluorescence quantum yield and brightness of these nanoparticles were evaluated by steady-state and dynamic fluorescence methods. The results demonstrate that the quantum yield and brightness of the fluorescent nanoparticles correlated directly with the number of dyes/nanoparticle and the nanoparticle size. A strategy to increase the fluorescence brightness of nanoparticles with fluorescein and near-infrared dyes is proposed.

Graphical abstract: Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

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Publication details

The article was received on 13 Oct 2009, accepted on 08 Dec 2009 and first published on 08 Feb 2010


Article type: Paper
DOI: 10.1039/B9NR00304E
Nanoscale, 2010,2, 548-558

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    Bright fluorescent nanoparticles for developing potential optical imaging contrast agents

    G. Sun, M. Y. Berezin, J. Fan, H. Lee, J. Ma, K. Zhang, K. L. Wooley and S. Achilefu, Nanoscale, 2010, 2, 548
    DOI: 10.1039/B9NR00304E

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